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Every year, more than a thousand adults and children in Hong Kong are diagnosed with leukaemia and other serious blood diseases. Some of these diseases can be life-threatening, but are not always incurable. For many patients, bone marrow transplantation may be the only hope for a cure. However, a matched donor has to be identified before transplantation can be performed. Some patients are fortunate enough to have a suitable donor within their families, yet others will need to find unrelated persons to help. 


Hong Kong Bone Marrow Donor Registry (HKBMDR) Background

In 1991, sixteen-month-old Gordon Wu, a Chinese Canadian, was urgently in need of bone marrow transplantation to treat a serious blood disease. Since no suitable donor could be found within his family or among unrelated donors world-wide, his parents brought him to Hong Kong to launch the "Save Little Gordon" campaign. Since then, the Hong Kong Marrow Match Foundation ("HKMMF") was established. The campaign has raised tremendous public awareness about bone marrow donation and within a few weeks, about 13,000 people registered for bone marrow donation. This was the world's first all-Chinese bone marrow donor registry.

 As at the end of 2022, more than 167,000 people in Hong Kong have registered for voluntary bone marrow donation, and 693 of them have already donated their bone marrow to patients. In addition, the HKBMDR has successfully facilitated matched unrelated haematopoietic stem cells for transplantation for 1260 local and overseas patients.

 Starting from 1 September 2005, the HKMMF transferred the management of the donor data to the Hong Kong Red Cross ("HKRC"). The latter has also set up a new registry called the Hong Kong Bone Marrow Donor Registry ("HKBMDR"). HKBMDR will also focus its effort predominantly on bone marrow transplantation research and public education. It will continue to liaise with international bone marrow registries and assist patients who require bone marrow transplantation. On the same date, both HKMMF and HKRC have appointed the Hong Kong Red Cross Blood Transfusion Service ("BTS"), which is operated by the Hospital Authority, as their agent to access and use the donor data in the HKMMF and the HKBMDR. The BTS will perform the bone marrow services previously provided by the HKMMF. These services include managing and operating the HKMMF and HKBMDR, providing tissue typing for both patients and donors, and other related services.

Image: Milestones of unrelated Bone Marrow Donation in Hong Kong
Service Scope

1. Donor recruitment

 Public can register as a marrow donor by attending one of the donor centres / mobile donation service / mobile donation vehicles in HKRCBTS.

 2. Donor Search

Hong Kong Bone Marrow Donor Registry (HKBMDR) is the only registry in Hong Kong for voluntary unrelated bone marrow donors. We help local and overseas patients in need of hematopoietic stem cell (HSC) transplant to find suitable donors.

Information of registered donors is kept in the registry. When a donor search is initiated, the BTS will try to find a matched donor in the registry. If a potential donor is found, the BTS will closely liaise with the donor and the patient's hospital and to arrange the donor for medical checkup as well as other follow-up works.

 If potential matched donors cannot be identified in Hong Kong, HKBMDR will contact the overseas registries to request a search for potential donors. All the search request must be submitted and referred from hospital to HKBMDR. HKBMDR will undergo a computer search for matched donors. Under normal circumstances, several blood tests may be required before a highly matched or full matched donors be identified. If the patients and their family members wish to know the search progress, they are advised to contact their doctor in-charge.

Who is a matched donor?

The most important factor is to match both donor's and recipient's tissue types (also known as "HLA antigens"). Red blood cells are grouped into types A, B, AB and O, etc. As for white blood cells, they also have tissue types mainly classified into 4 groups, namely A, B, C and DR groups. Each group has a large number of antigens and hence there are thousands of different tissue types for white blood cells.

Prospective donors will need to have blood tested to determine his/her tissue types. If the tissue types of a donor completely match with the patient, he/she will be a matched donor.

Image:  HLA antigens