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Peripheral Blood Stem Cell Donation

Peripheral Blood Stem Cell Donation

In addition to bone marrow donation, now the haematopoietic stem cells (HSC) collection procedure can be taken place at the outpatient hospital unit.

For 3 days leading up to donation, you will be given subcutaneous injections of a drug called filgrastim to mobilize the number of HSC in your bloodstream.
Your blood will be separated and HSC could be collected by using an apheresis machine. The remaining blood will be returned to you during the procedure.
 
Collection procedure can be taken without general anaesthesia and lasts 3 to 4 hours. However, in case the first collection does not yield the required quanitity of HSC, the donor may be rquired to make a second donation on the next day.
Image: Peripheral Blood Stem Cell Donation
Peripheral Blood Stem Cell Donation

Step One

2 – 3 weeks prior to donation:  Donor will be invited for Physical examination such as chest X-ray, ECG…..etc. Then we will review the workup report and confirm details of donation
 
Step Two
In order to be able to donate enough Peripheral Blood Stem Cell Donation (PBSC) for a transplant, more of the haematopoietic stem cells need to be mobilized from the marrow into the blood stream. Donor is requested to receive Granulocyte Colony Stimulating Factor ( G-CSF) subcutaneous injection each day for three days before the donation.
 
Step One
2 – 3 weeks prior to donation:  Donor will be invited for Physical examination such as chest X-ray, ECG…..etc. Then we will review the workup report and confirm details of donation
 
Step Three 
Donating PBSC is through a standard process called apheresis.
During donation, a needle will be placed into each of your arms.  Blood will be moved from a vein in one arm and passed through tubing into a blood cell separator machine.  The blood is spun at high speed and the blood cells separate into layers. 
PBSC is collected, while the plasma, red blood cells and other blood cells are returned to you through the other arm.  Generally, most of the PBSC donations are completed in one apheresis session which may take up to four hours and the volume is less than 250 ml.  Hospitalization and General Anesthesia are not required. Donor could be discharged on the same day.
 
Step Four 
Generally, donor would be recovered and return to normal in one to two days.
 
Step Five
Keep the hope alive! Thank you for making life-saving transplants a reality for patients! 
 You make a difference! Your donation has given the chance of life for patient. You are a lifesaver